Jennifer Hermoso Fuentes was born on 9 May 1990 in Madrid, Spain, and developed in the youth system of Atlético Madrid. After establishing herself in senior football, she moved to Rayo Vallecano and later spent a season in Sweden with Tyresö FF before joining Barcelona. Hermoso developed into one of Spain's outstanding attacking players, combining goalscoring with technical ability and creative play.
Hermoso enjoyed two highly successful spells with Barcelona, scoring 181 goals in 224 official appearances for the club. She won the Spanish league five times with Barcelona and was part of the historic team that won the UEFA Women's Champions League and completed the treble in 2020/21. She also represented Paris Saint-Germain and returned to Atlético Madrid before moving to Mexico in 2022, first with Pachuca and later Tigres UANL.
Hermoso made her senior Spain debut in June 2012 and developed into the national team's all-time leading goalscorer. She represented Spain at multiple European Championships and World Cups and played an important role in the team that won the 2023 FIFA Women's World Cup. Her longevity, goalscoring record and success at both club and international level have made her one of the defining Spanish players of her generation.

Hermoso has been involved in advocacy for equality and institutional reform in women's football. In 2024, she received the Sócrates Award in recognition of her humanitarian work and her role in promoting positive social change.